27 Aug

Potential novel biomarkers found for fibromyalgia and rheumatoid arthritis related pain

A significant paper resulting from the GLORIA project was published recently in Journal of Proteomics. The study conducted by several GLORIA groups at the Karolinska Institute, Stockholm, Sweden, and led by Jon Lampa found several potential pain related biomarkers by analyzing the cerebrospinal fluid of patients suffering from fibromyalgia and rheumatoid arthritis. Their findings could be important for understanding the mechanism of chronic pain as well as for diagnostic purposes in patients. The full paper can be freely read here.

 

Khoonsari PE, Ossipova E, Lengqvist J, Svensson CI, Kosek E, Kadetoff D, Jakobsson PJ, Kultima K, Lampa J.
The human CSF pain proteome.
J Proteomics. 2018. pii: S1874-3919(18)30224-0.

27 Aug

The neuroimmune signalling is different between male and female patients suffering from knee osteoarthritis

An important GLORIA project-based paper was recently published in Journal of Neuroimmunology. Eva Kosek et al. compared cytokine levels in the cerebrospinal fluid, serum and synovial fluid of patients suffering from knee osteoarthritis. They discovered differences in the cytokine levels between males and females pointing out to sex differences in the signalling between the nervous system and the immune system. They also found that neuroinflammation in osteoarthritis might be a neuroprotective mechanism, and targeting the neuroimmune communication could be a novel treatment strategy for osteoarthritis when differences between males and females are taken into account. The full publication can be freely read here.

 

Kosek E, Finn A, Ultenius C, Gedin P, Hugo A, Gladh I, Andersson M, Svensson C, Ahmed A. Differences in neuroimmune signalling between male and female patients suffering from knee osteoarthritis.
J Neuroimmunology. 2018; 321: 49-60.

18 Jun

Developing new drugs for chronic pain:  focus on opioids and glia 

GLORIA was a co-organizer of the course “Developing new drugs for chronic pain: Focus on opioids and glia” together with Drug Research Doctoral Programme (DRDP) and Doctoral Programme in Clinical Veterinary Medicine (DPCVM). The course aimed mainly for PhD students of various backgrounds coveedr the process of developing novel analgesics, starting from the need for a new drug, till the development of lead molecules.

The course took place in Helsinki, September 8–10, 2014.