An important GLORIA project-based paper was recently published in Journal of Neuroimmunology. Eva Kosek et al. compared cytokine levels in the cerebrospinal fluid, serum and synovial fluid of patients suffering from knee osteoarthritis. They discovered differences in the cytokine levels between males and females pointing out to sex differences in the signalling between the nervous system and the immune system. They also found that neuroinflammation in osteoarthritis might be a neuroprotective mechanism, and targeting the neuroimmune communication could be a novel treatment strategy for osteoarthritis when differences between males and females are taken into account. The full publication can be freely read here.
Kosek E, Finn A, Ultenius C, Gedin P, Hugo A, Gladh I, Andersson M, Svensson C, Ahmed A. Differences in neuroimmune signalling between male and female patients suffering from knee osteoarthritis.
J Neuroimmunology. 2018; 321: 49-60.