Tando Maduna T, Audouard E, Dembélé D, Mouzaoui N, Reiss D, Massotte D, Gaveriaux-Ruff C.
Microglia Express Mu Opioid Receptor: Insights from Transcriptomics and Fluorescent Reporter Mice.
Front Psychiatry. 2018
Link to article

Ahonen TJ, Savinainen JR, Yli-Kauhaluoma J, Kalso E, Laitinen JT, Moreira VM.
Discovery of 12-thiazole abietanes as selective inhibitors of the human metabolic serine hydrolase hABHD16A.

ACS Med Chem Lett. 2018
Link to article

Tobin SJ, Wakefield DL, Terenius L, Vukojević V, Jovanović-Talisman T.
Ethanol and Naltrexone Have Distinct Effects on the Lateral Nano-organization of Mu and Kappa Opioid Receptors in the Plasma Membrane.
ACS Chem Neurosci. 2018
Link to article

Lötsch J, Lerch F, Djaldetti R, Tegeder I, Ultsch A.
Identification of disease-distinct complex biomarker patterns by means of unsupervised machine-learningf using an interactive R toolbox (Umatrix).
Big Data Anal. 2018; 3: 5
Link to article

Krock E, Jurczak A, Svensson CI.
Pain pathogenesis in rheumatoid arthritis-what have we learned from animal models?
Pain. 2018; 159 Suppl 1:S98-S109.
Link to article

Ivanova L, Tammiku-Taul J, García-Sosa AT, Sidorova Y, Saarma M, Karelson M.
Molecular Dynamics Simulations of the Interactions between Glial Cell Line-Derived Neurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands.
ACS Omega. 2018; 3(9):11407-11414.
Link to article

Article by Ceredig RA, Pierre F, Doridot S, Alduntzin U, Salvat E, Yalcin I, Gaveriaux-Ruff C, Barrot M, Massotte D.
Peripheral delta opioid receptors mediate duloxetine antiallodynic effect in a mouse model of neuropathic pain.
Eur J Neurosci. 2018;  48:2231-2246.
Link to article

Palada V, Ahmed AS, Finn A, Berg S, Svensson CI, Kosek E.
Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease.
Brain Behav Immun. 2018; pii: S0889-1591(18)30580-4.
Link to article

Albrecht DS, Forsberg A, Sandstrom A, Bergan C, Kadetoff D, Protsenko E, Lampa J, Lee YC, Olgart Höglund C, Catana C, Cervenka S, Akeju O, Lekander M, Cohen G, Halldin C, Taylor N, Kim M, Hooker JM, Edwards RR, Napadow V, Kosek E, Loggia ML.
Brain glial activation in fibromyalgia – a multi-site positron emission tomography investigation.

Brain Behav Immun. 2018; pii: S0889-1591(18)30242-3.
Link to article

Fernandez-Zafra T, Gao T, Jurczak A, Sandor K, Hore Z, Mohan Agalave N, Su J, Estelius J, Lampa J, Hokfelt T, Wiesenfeld-Hallin Z, Xu X, Denk F, Svensson CI.
Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis.
Pain. 2018; doi: 10.1097/j.pain.0000000000001394.
Link to article

Lötsch J, Sipilä R, Dimova V, Kalso E.
Machine-learned selection of psychological questionnaire items relevant to the development of persistent pain after breast cancer surgery.
Br J Anaesth. 2018; 121(5): 1123-1132.
Link to article

Suleymanova I, Balassa T, Tripathi S, Molnar C, Saarma M, Sidorova Y, Horvath P.
A deep convolutional neural network approach for astrocyte detection.
Sci Rep. 2018; 8(1): 12878.

Link to article

Kosek E, Finn A, Ultenius C, Gedin P, Hugo A, Gladh I, Andersson M, Svensson C, Ahmed A.
Differences in neuroimmune signalling between male and female patients suffering from knee osteoarthritis.
J Neuroimmunology. 2018; 321: 49-60.
Link to article

Kringel D, Lippmann C, Parnham MJ, Kalso E, Ultsch A, Lötsch J.
A machine-learned analysis of human gene polymorphisms modulating persisting pain points at major roles of neuroimmune processes.
Eur J Pain. 2018; doi: 10.1002/ejp.1270. [Epub ahead of print]
Link to article

Lötsch J, Sipilä R, Tasmuth T, Kringel D, Estlander AM, Meretoja T, Kalso E, Ultsch A.
Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy.
Breast Cancer Res Treat. 2018. doi: 10.1007/s10549-018-4841-8. [Epub ahead of print]
Link to article

Kringel D, Geisslinger G, Resch E, Oertel BG, Thrun MC, Heinemann S, Lötsch J.
Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin.
Pain. 2018; 159(7): 1366-1381.
Link to article

Khoonsari PE, Ossipova E, Lengqvist J, Svensson CI, Kosek E, Kadetoff D, Jakobsson PJ, Kultima K, Lampa J.
The human CSF pain proteome.
J Proteomics. 2018
. pii: S1874-3919(18)30224-0.
Link to article

Ahonen TJ, Rinne M, Grutschreiber P, Mätlik K, Airavaara M, Schaarschmidt D, Lang H, Reiss D, Xhaard H, Gaveriaux-Ruff C, Yli-Kauhaluoma J, Moreira.
Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors.
Eur J Med Chem. 2018; 151: 495-507.
Link to article

Jokinen V, Sidorova Y, Viisanen H, Suleymanova I, Tiilikainen H, Li Z, Lilius TO, Mätlik K, Anttila JE, Airavaara M, Tian L, Rauhala PV, Kalso EA.
Differential spinal and supraspinal activation of glia in a rat model of morphine tolerance.
Neuroscience. 2018; 375: 10-24.
Link to article

Lilius T, Kangas E, Niemi M, Rauhala P, Kalso E.
Ketamine and norketamine attenuate oxycodone tolerance markedly less than that of morphine: from behaviour to drug availability.
Br J Anaesth. 2018; 120: 818-826.
Link to article

Ivanova L, Tammiku-Taul J, Sidorova Y, Saarma M, Karelson M.
Small-Molecule Ligands as Potential GDNF Family Receptor Agonists.
ACS Omega. 2018; 3: 1022-1030.
Link to article

Lötsch J and  Kringel D.
Use of computational functional genomics in drug discovery and repurposing for analgesic indications.
Clin Pharmacol Ther. 2018; 103(6): 975-978.
Link to article

Lilius TO, Viisanen H, Jokinen V, Niemi M, Kalso EA, Rauhala PV.
Interactions of (2S,6S;2R,6R)-hydroxynorketamine, a secondary metabolite of (R,S)-ketamine, with morphine.
Basic Clin Pharmacol Toxicol. 2018; 122(5):481-488.
Link to article


Lötsch J, Lippmann C, Kringel D, Ultsch A.
Integrated computational analysis of genes associated with human hereditary insensitivity to pain. A drug repurposing perspective.
Front Mol Neurosci. 2017; 10: 252. eCollection 2017.
Link to article

Roeckel LA, Utard V, Reiss D, Mouheiche J, Maurin H, Robé A, Audouard E, Wood JN, Goumon Y, Simonin F, Gaveriaux-Ruff C.
Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide.
Sci Rep. 2017; 7: 10406
Link to article

Sidorova YA, Bespalov MM, Wong AW, Kambur O, Jokinen V, Lilius TO, Suleymanova I, Karelson G, Rauhala PV, Karelson M, Osborne PB, Keast JR, Kalso EA, Saarma M.
A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat.
Front Pharmacol. 2017; 8: 365. eCollection 2017.
Link to article

Tour J, Löfgren M, Mannerkorpi K, Gerdle B, Larsson A, Palstam A, Bileviciute-Ljungar I, Bjersing J, Martin I, Ernberg M, Schalling M, Kosek E.
Gene-to-gene interactions regulate endogenous pain modulation in fibromyalgia patients and healthy controls – antagonistic effects between opioid and serotonin-related genes.
Pain. 2017; 158(7): 1194-1203.
Link to article

Kringel D, Sisignano M, Zinn S, Lötsch J.
Next-generation sequencing of the human TRPV1 gene and the regulating co-players LTB4R and LTB4R2 based on a custom AmpliSeq™ panel.
PLoS One. 2017; 12(6): e0180116.
Link to article

Lötsch J, Ultsch A, Kalso E.
Prediction of persistent post-surgery pain by preoperative cold pain sensitivity: Biomarker development with machine-learning-derived analysis.
Br J Anaesth. 2017; 119(4): 821-829.
Link to article

Ultsch A and Lötsch J.
Machine-learned cluster identification in high-dimensional data.
J Biomed Inform. 2017; 66: 95-104.
Link to article


Jokinen V, Lilius TO, Laitila J, Niemi M, Rauhala PV, Kalso EA.
Pregabalin enhances the antinociceptive effect of oxycodone and morphine in thermal models of nociception in the rat without any pharmacokinetic interactions.
Eur J Pain. 2016; 20(2): 297-306.
Link to articleJokinen et al. Pregabalin 2016_Full Text

Kosek E, Martinsen S, Gerdle B, Mannerkorpi K, Löfgren M, Bileviciute-Ljungar I, Fransson P, Schalling M, Ingvar M, Ernberg M, Jensen KB.
The translocator protein gene is associated with symptom severity and cerebral pain processing in fibromyalgia.
Brain Behav Immun. 2016; 58: 218-227.
Link to article

Kanegawa N, Collste K, Forsberg A, Schain M, Arakawa R, Jucaite A, Lekander M, Olgart Höglund C, Kosek E, Halldin C, Farde L, Varrone A, Cervenka S.
In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects.
Brain Behav Immun. 2016. 54: 149-157.
Link to article; Kanegawa et al. 2016 Full Text

Flodin P, Martinsen S, Altawil R, Waldheim E, Lampa J, Kosek E, Fransson P.
Intrinsic brain connectivity in chronic pain: A resting-state fMRI study in patients with rheumatoid arthritis.
Front Hum Neurosci. 2016; 10: 107. eCollection 2016.
Link to article

Li ZL, Wei H, Piirainen S, Chen ZY, Kalso E, Pertovaara A, and Tian L.
Spinal versus brain microglial and macrophage activation traits determine the differential neuroinflammatory responses and analgesic effect of minocycline in chronic neuropathic pain.
Brain Behav. Immun. 2016; 58: 107-117.
Link to article

Altawil R, Saevarsdottir S, Wedrén S, Alfredsson L, Klareskog L, Lampa J.
Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate.
Arthritis Care Res. 2016; 68(8): 1061-1068.
Link to article

Roeckel LA, Le Coz GM, Gavériaux-Ruff C, Simonin F.
Opioid-induced hyperalgesia: Cellular and molecular mechanisms.
Neuroscience. 2016; 338: 160-182.
Link to articleRoeckel et al. 2016 Opioid-induced hyperalgesia_Full text

Kringel D, Ultsch A, Zimmermann M, Jansen JP, Ilias W, Freynhagen R, Griessinger N, Kopf A, Stein C, Doehring A, Resch E, and Lötsch J.
Emergent biomarker derived from next generation sequencing to identify pain patients requiring uncommonly high opioid doses.
Pharmacogenomics J. 2016; 17: 419-426.
Link to article

Kringel D and Lötsch J.
Next-generation sequencing of human opioid receptor genes based on a custom AmpliSeq™ library and ion torrent personal genome machine.
Clin Chim Acta. 2016; 463: 32-38.
Link to article


Kosek E, Altawil R, Kadetoff D, Finn A, Westman M, Le MaÎtre E, Andersson M, Jensen-Urstad M, Lampa J.
Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain – Interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis.
J Neuroimmunol. 2015; 280: 49-55.
Link to article

Su J, Gao T, Shi T-J, Xu, X, Wiesenfeld-Hallin Z, Hokfelt, T, Svensson CI.
Phenotypic changes in dorsal root ganglion and spinal cord in the collagen antibody-induced arthritis mouse model.
J Comp Neurol. 2015; 523(10): 1505-1528.
Link to article

Kringel D and Lötsch J.
Pain research funding by the European Union Seventh Framework Programme.
Eur J Pain. 2015; 19: 595-600.
Link to article

Lilius TO, Jokinen V, Neuvonen MS, Niemi M, Kalso EA and Rauhala PV.
Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat.
Br J Pharmacol. 2015; 172(11): 2799-2813.
Link to article


Agalave NM, Larsson M, Abdelmoaty S, Su J, Baharpoor A, Lundbäck P, Palmblad K, Andersson U, Harris H, Svensson CI.
Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis.
Pain. 2014; 155(9): 1802-13.
Link to article

Ultsch A and Lötsch J.
What do all the (human) micro-RNAs do?
BMC Genomics. 2014; 15: 976
Link to article 

Relevant previous work

Meretoja TJ, Leidenius MK, Tasmuth T, Sipilä R, Kalso E.
Pain at 12 Months After Surgery for Breast Cancer

JAMA. 2014; 311(1): 90-92. 
Link to article